On the Ewing sarcoma cells carrying a cancer-related translocation t(11;22), it has been noted that the fusion genes EWSR1/FLI1 and ABL1/BCR were observed in an intermediate nuclear position when compared to the wild type EWSR1 and FLI1 genes and that this location seems to depend to the chimeric chromosomes obtained by the translocation [98]. Here, EWSR1 is linked to Ewing sarcoma.