Most patients with ccRCC show chromosomal 3p loss and genomic mutations in the Von Hippel-Lindau Tumor Suppressor (VHL) allele [8], followed by secondary loss of multiple tumor suppressor genes, including PBRM1, SETD2, BAP1, and/or KDM5C [9]. This evidence concerns the gene VHL and nonpapillary renal cell carcinoma.