As RCC progressed from early to locally advanced and metastatic diseases, there was a consistent increase in the frequency of terminally exhausted CD8+ T cells, Treg, CD14+ monocytes, and immune suppressive M2-like TAMs, and a general decrease in the frequency of cytotoxic CD8+ T cells, central memory CD4+ T cells, and inflammatory M1-like TAMs. The gene discussed is CD8A; the disease is metastatic neoplasm.