In studies evaluating ICI in combination with anti-VEGF or TKIs as a first-line therapy, it significantly improved the clinical outcome in patients with ccRCC, showing an objective response rate (ORR) of 50 to 59%, including 4 to 12% complete response (CR) rates, depending on experimental settings [21,22,23,24,25]. This evidence concerns the gene VEGFA and nonpapillary renal cell carcinoma.