The univariate analysis showed that age ≥ 85 years, CCI score ≥ 5, male sex, low BMI, low albumin, high WBC, low Hb, high CEA, high NLR, low PNI, low GNRI, T4 tumor grade, high number of lymph node metastases, poor histological features and grade, and emergency surgery were associated with poor OS. The gene discussed is CEACAM5; the disease is neoplasm.