Both the mutations and amplifications of c-KIT are uncommon in cutaneous melanomas (3–4%) but are enriched in acral (8.6–36%) and mucosal melanomas (9.6–39%) (KIT mutations are enriched in sinonasal mucosal melanomas, as opposed to anogenital) [50,51,52,53]. The gene discussed is KIT; the disease is mucosal melanoma.