Currently known associations with HLA alleles include HLA-B*51/52 (B5) as a risk and HLA-DRB1*07 as a protective allele for cHL overall; HLA-A*01, HLA-B*37, and HLA-DRB1*10 as risk and HLA-A*02 as protective alleles for EBV+ cHL; and HLA-DRB1*11/12 (DR5) and HLA-DRB1*15/16 (DR2) as risk alleles for EBV− cHL [15,16,17,18]. This evidence concerns the gene HLA-A and classic Hodgkin lymphoma.