In the CORAL (Collaborative Trial in Relapsed Aggressive Lymphoma) study, relapsed 8q24/MYC positive DLBCL had an inferior 4-year progression-free survival (PFS) (18% vs. 42%) and overall survival (OS) (29% vs. 62%), with salvage chemotherapy followed by autologous stem cell transplant (autoSCT), when compared to MYC negative DLBCL [4]. This evidence concerns the gene MYC and diffuse large B-cell lymphoma.