Schimtz et al. identified four genetic subtypes of DLBCL using exome and transcriptome sequencing: MCD (co-occurrence of MYD88L265P and CD79B mutations), BN2 (BCL6 fusions and NOTCH2 mutations), N1 (NOTCH1 mutations), and EZB (EZH2 mutations and BCL2 translocations). Here, NOTCH2 is linked to diffuse large B-cell lymphoma.