PML was first identified as a component of PML-RARα fusion protein in acute promyelocytic leukemia [53,54,55,56], and in addition to its well-known functions in DNA damage response, apoptosis, and senescence, investigations over the last decade have identified PML as a regulator of metabolic pathways in stem cell compartments, including the hematopoietic system. This evidence concerns the gene PML and acute promyelocytic leukemia.