CD44 and chronic myelogenous leukemia, BCR-ABL1 positive: Upregulation of CD44, along with increased binding to E-selectin, is observed in BCR-ABL-expressing cells with the T315I mutation, and these cells, which adhere to stromal cells, are quiescent [37], suggesting that these alterations of extrinsic factors by CML LSCs promote exclusive LSC lodging and dormancy, allowing them to escape TKI targeting.