In agreement with our in vitro results, in silico analysis of Reverse-phase Protein Arrays (RPPA) data from a cohort of patients (TCGA-GBM dataset) showed a significant positive correlation between Tau expression and Akt activity since lower levels of AktSer473 phosphorylation were found in human glioblastoma expressing low levels of Tau RNA (MAPT p < 0.01). The gene discussed is MAPT; the disease is glioblastoma.