EGFR and infectious otitis media: To study the effect of a nutritional intervention in the presence or absence of anti-EGFR Ab treatment on the progression of pre-existing CRC in mice, we first induced sporadic colitis-driven CRC in C57BL/6 mice until day 70 by intraperitoneal (i.p.) injection of 10 mg/kg/body weight (BW) AOM at day zero and a second i.p. injection of 5 mg/kg/BW AOM at day 21.