Importantly, proteomic profiling on resveratrol treatment has shed light on the pivotal cell signaling pathways and has highlighted molecular and immunomodulatory signatures such as Serpin (HSP47) and Anterior gradient protein 2- a protein disulfide isomerase with implications for chemo-immunotherapy as well as the development of anticancer vaccines for adenocarcinoma of the esophagus. This evidence concerns the gene SERPINH1 and esophageal adenocarcinoma.