Similar to aberrant IL-7Rα signaling, the PI3K/AKT/mTOR and JAK/STAT pathways are associated with rearrangements of the CRLF2 gene, leading to the development of Philadelphia-like (Ph-like) ALL, which can portend a poorer prognosis compared to those without the mutation [78,79]. Here, CRLF2 is linked to acute lymphoblastic leukemia.