DHODH and neoplasm: These results are also supported by the recent data obtained by Bajzikova et al., which confirm the importance of mtDNA transfer from host cells to tumor cells in the reconstitution of OXPHOS, showing that pyrimidine biosynthesis dependent on respiration-linked dihydroorotate dehydrogenase (DHODH) is necessary for tumor growth, and that mitochondrial ATP generation is actually unessential for tumorigenesis [122].