TNF and cancer: In addition, among the enriched signaling pathways, including those of necroptosis, MAPK, NOD-like receptor, focal adhesion, small cell lung cancer, GnRH, IL-17, TNF, apoptosis, ECM-receptor interaction, choline metabolism in cancer, and linoleic acid metabolism (Figure 6B), many have not been reported for their involvement in the anticancer effects of other cardiac glycosides.