Moreover, siRNA-mediated silencing of FGFR4 in CRC cells decreased the expression of Bcl-2 and c-FLIP (FLICE-like inhibitory protein), an inhibitor of caspase 8, while reducing STAT3 activity, which in turn induced caspase-dependent apoptosis (Figure 3) [52]. This evidence concerns the gene FGFR4 and colorectal carcinoma.