In another study, the interaction of FGFR4 with the βKlotho (KLB) co-receptor, a metabolic regulator that is frequently disrupted in hepatic cancers, was shown to inhibit cell proliferation and induce caspase-3-dependent apoptosis in hepatomas by decreasing AKT and mTOR activity [250]. This evidence concerns the gene FGFR4 and hepatocellular carcinoma.