Overexpression of FGF14 in NSCLC LUAC cell line (A549) resulted in decreased proliferation, colony formation and migration, and enhanced mesenchymal to epithelial transition, indicating that FGF14 reduces the invasiveness of lung cancer cells in vitro while ablation of FGF14 in these cells reversed the above changes, supporting its suppressive role in lung cancer progression. The gene discussed is FGF14; the disease is non-small cell lung carcinoma.