In HER-positive breast cancer, the secretion of FGF5 by CAFs leads to FGFR2 activation in cancer cells and acquisition of resistance to trastuzumab and lapatinib (EGFR/HER2 inhibitors) through FGFR2/c-Src-mediated HER2 transactivation [112]. Here, ERBB2 is linked to breast cancer.