In addition, FGF2 secreted by CAFs was found to contribute to lung cancer cells growth through overexpression of Tgfb, Mmp7, Fgf2, Fgf9, enhanced collagen synthesis, and increased expression of inflammatory cytokines such as Csf1, Cxcl12, and Ccl2 [109]. The gene discussed is FGF2; the disease is lung cancer.