FOLH1 and neoplasm: Thus, the experimental arm of the HypoFocal-SBRT trial combines (i) state of the art diagnostic imaging (mpMRI and PSMA-PET/CT) in order to accurately depict the ITM and to exclude distant metastases, with (ii) high-precision ablative RT in terms of SBRT in order to (i) improve tumor control without increasing toxicity and/or impairing quality of life (QoL), but to (ii) reduce the treatment time and thus increase patients’ convenience.