FOLH1 and posterior cortical atrophy: Therefore, the HypoFocal-SBRT study integrates advanced biological imaging techniques for boosting the ITM (mpMRI and PSMA-PET) with high precision RT concepts in terms of SBRT in the experimental arm for patients with primary localized unfavorable intermediate- and high-risk PCa compared to a homogeneously delivered MHRT to the entire prostatic gland in the control arm of the study.