CD4 and neoplasm: Following RFA of HCC, as well as of other tumors, a release of DAMPs, including RNA, DNA, HSPs, and HMGB1 [69,70], and an increase in inflammatory cytokines, such as IL-1β, IL-6, IL-8, TNF-α, and IFN-γ [34,52,71,72,73], in tumor specific antibodies, CD4+ T cells, CD8+ T cells, tumor-specific T cells [34,37,74], central memory lymphocytes (CD45RA-/CCR7+) [74,75], and in infiltrating CD45RO+ memory T cells have been demonstrated [34].