CD8A and liver cancer: When considering the potential immunological effect of laser ablation, in mice models of liver cancer, LITT was followed by eradication of a subsequent challenging tumor and absence of tumor spread, and it was associated with an increased number of macrophages and CD8 T cells; expression of HSP70, HSP90, and HSP27; serum levels of IL-6 and TNF receptor [151,152,153].