CD8A and neoplasm: For histotripsy, evidence of local and systemic inflammatory response has been reported in melanoma tumors in mice, with increased levels of intratumoral NK, DC, neutrophil, B and T cells, and increased levels of circulating NK cells; moreover, histotripsy led to inhibition of metastatic growth, and significantly higher levels of CD8+ T-cell infiltration into distant tumor sites were recorded after contralateral histotripsy ablation [141].