Indeed, the analysis of primary melanoma in comparison to benign nevi showed a reduced expression of the proautophagic proteins Atg5, beclin-1, microtubule-associated protein 1A/1B-light chain 3 (LC3A and LC3B); moreover, the expression levels of p62, a ubiquitin-binding scaffold protein also called sequestosome-1, and activating molecule in Beclin 1-regulated autophagy protein 1 (AMBRA1), have been proposed as prognostic biomarkers of early-stage melanoma [66,67,68]. Here, ATG5 is linked to melanoma.