Here we reported on a patient with high-risk stage 4 NB and adverse clinical behavior presenting a tumor carrying high-grade amplification of six loci besides MYCN, including the genes MYT1L, TSSC1, CMPK2, RSAD2, RNF144A, GREB1, NTSR2, LPIN1, NBAS, and the two long intergenic non-protein coding RNAs LOC730811 and LOC339788. Here, GREB1 is linked to neuroblastoma.