A potential synergistic oncogenic effect between SARS-CoV-2 and obesity is insinuated by the in vitro ability of the downregulation of p53 protein to mediate the obesity-driven tumor progression attributed to increased levels of C1q/TNF-related protein 1 (CTRP1), an adiponectin paralog [103]. The gene discussed is ADIPOQ; the disease is obesity due to melanocortin 4 receptor deficiency.