This important result has potential clinical applications, particularly for patients belonging to the unfavourable cluster B. Cluster B was associated with the frailest patients with larger tumour mass (i.e., metastatic disease) mainly driven by high inflammation (CRP) at baseline and a negative protein balance (albumin) during study follow-up, suggesting a more aggressive cancer with a high risk of cancer-cachexia [19]. The gene discussed is CRP; the disease is cancer.