In recent years, research has mainly focused on the role of pro-inflammatory cytokines, such as interleukin-6 (IL-6), interleukin-1 (IL-1), tumor necrosis factor alpha (TNF-α), and interferon gamma (IFN-γ), and confirmed their involvement in the pathogenesis of cachexia [8,9,10,11]. The gene discussed is TNF; the disease is Cachexia.