Low concentrations of NO promote cancer cell proliferation and progression by the Warburg effect, while higher concentrations of NO induce DNA damage and apoptosis in cancer cells by activating the apoptosis signal-regulating kinase 1 (ASK1)/c-Jun N-terminal protein kinase (JNK1), BCL-2-associated X protein (BAX), and BCL-2 homologous antagonist killer (BAK) pathways [8,9,10]. This evidence concerns the gene MAP3K5 and cancer.