While lymphocytes, myeloid, and plasma cells stain negative for FSCN1, in human hematologic malignancies including HIV-related lymphoid hyperplasia, Reed-Sternberg cells, Hodgkin’s lymphoma, Castleman’s disease, and other lymphoid hyperplasia, FSCN1 is overexpressed [174,175]. This evidence concerns the gene FSCN1 and Hodgkins lymphoma.