FSCN1 and familial pancreatic carcinoma: Similar to all gastrointestinal cancers, in pancreatic cancer, there is an increase in FSCN1 expression during carcinogenesis progression (from pancreatic intraepithelial neoplasia to pancreatic adenocarcinoma); high FSCN1 expression correlates with higher histological grades, and poor overall survival [40,41,173].