In a study, (14E, 18E, 22E, 26E)-methyl nonacosa-14, 18, 22, 26 tetraenoate, a fatty acid isolated from A. spinosus, first demonstrated its potent ability to inhibit HepG2 HCC cell proliferation and apoptosis via upregulation of Bax and downregulation of Bcl-2 and cyclin B1, when administered at a dose of 25.52 μmol/L [46]. The gene discussed is BCL2; the disease is hepatocellular carcinoma.