MAP2K1 and neoplasm: Of note, there was also a statistically significant negative association between mutation in NGS of the FGFR3 gene (HR = 0.03 (0.00–0.26); p = 0.001) and the MAP2K1 gene (HR = 0.03 (0.00–0.26); p = 0.001) and OS; however, given the small number of patients with a tumor harbouring these mutations, these results were not included in the multivariate analysis.