PBRM1 and neoplasm: Two tumors (Cases 34 and 70) had FBXW7 mutations, which has been reported as a tumor suppressor gene [28,29]; one sample carried the mutation in exon 12, c.1856-2A > G; and another sample carried exon 4, c.585-1G > T. One tumor (Case 34) had a mutation (exon 11, c.996-1G > T) of PBRM1, which is the second most common tumor suppressor gene in kidney cancer.