The suppression of miR-424 by E6 and E7 further results in CHK1 induction targeting DNA damage repair [170], while low miR-424 expression is inversely correlated with CHK1 and p-CHK1 levels and associated with advanced FIGO stage, poor tumor differentiation, lymph node metastasis and LVSI [171]. The gene discussed is CHEK1; the disease is neoplasm.