Conversely, immunohistochemical detection of CD3 (pan T-cell marker), CD4, CD8, CD20 (B-cells) CD206 (macrophages) and Tregs in a smaller cohort of cervical cancer patients treated with CRT revealed an association of CD8+ TILS with pelvic lymph node metastases, while elevated levels of CD3+, CD4+, CD8+, CD206+ and FoxP3+ lymphocytes were associated with improved PFS and OS [237]. Here, CD4 is linked to metastatic malignant neoplasm in the lymph nodes.