Figure 4 illustrates the comparison of paired associations between total protein, SolCD44, mean number of CD44 expressed in epithelial layers in leukoplakia tissue, and macrophages in lamina propria between control group and patients with leukoplakia, where p < 0.0001 (****) indicates the level of statistical significance of between-group differences, regarding the analyzed parameters. Here, CD44 is linked to leukoplakia.