CD274 and neoplasm: Antibodies to programmed death-1 (PD-1) receptor and the programmed death ligand-1 (PD-L1) are specific kinds of ICI which function by inhibiting the binding of the programmed death-1 (PD-1) receptor to PD-L1, thus allowing tumor cells to be recognized as “other” and eliminated by a patient’s immune system (Figure 1) [1].