CD274 and neoplasm: It should be noted that the literature suggests that such an analysis could yield a different result; KEYNOTE-040 and -048 reported PD-L1 by CPS and demonstrated a significant correlation between PD-L1 and response to ICI [10,52,53], but CHECKMATE-141 failed to show a significant correlation between tumor response to Nivolumab and PD-L1 overexpression when PD-L1 was reported by TPS [5].