ABCB1 and cancer: Moreover, as further support for this possibility, an examination of gene expression data from the Cancer Cell Line Encyclopedia (CCLE) demonstrates significantly increased expression of MDR1/P-Glycoprotein in all three RCC cell lines (ACHN, 786-O, and CAKI-1 with FPKMs of 5.37, 10.70, and 3.95, respectively) used in this study compared with most lines used in prior DCLK1-IN-1 studies (Patu-8988T, Patu-8902, MKN1, and DLD1 with FPKMs of 0.009, 0.023, 0.046, and 10.4, respectively).