CD8A and neoplasm: In support of these findings, a recent organoid co-culture model in PDAC demonstrated that the overexpression of DCLK1 isoform 2 (Uniprot O15074-2; long-α) forces the conversion of M1 macrophages to M2 macrophages, which upon being educated suppress CD8+ T-cell mediated tumor cell death—a process that is reversible by DCLK1 downregulation [24].