Indeed, the Carli et al. study demonstrated that DCLK1 kinase activity directly regulates EV production and payload, leading to increased migration of GC cells [31], and thus it is tempting to speculate that part of DCLK1-IN-1′s anti-migratory/invasive function in RCC may exploit a similar mechanism. The gene discussed is DCLK1; the disease is renal cell carcinoma.