The overexpression of Ang2 in a rat glioma model led to aberrant vessel formation and decreased smooth muscle cell coverage [47] whereas Ang2-neutralizing antibodies decreased tumor growth [48] and also prevented VEGF-induced EC migration during angiogenesis [49], underscoring the role of Ang2 during VEGF-induced angiogenesis. This evidence concerns the gene ANGPT2 and glioma.