TNF-α at the RTbaseline (HR: 1.360, 95% CI: 1.011–1.829, p = 0.017) and FU1 (HR: 1.337, 95% CI: 1.061–1.686, p = 0.017) time points were inversely correlated with OS in the whole study population but also in the subgroup of lung cancer patients (RTbaseline: HR: 1.397, 95% CI: 1.009–1.935, p = 0.044). Here, TNF is linked to lung cancer.