In particular, during CLD, LSECs are influenced by DAMPs and pro-inflammatory mediators secreted by KC, activating the transcription of several adhesion molecules, such as ICAM, VCAM and stabilins, among others, which induce the adhesion and migration of leukocytes from the lumen of sinusoids into the liver tissue [56,57]. Here, CALCA is linked to congenital secretory chloride diarrhea 1.