CD274 and congenital secretory chloride diarrhea 1: On the other hand, other vascular deregulations in the cirrhotic liver, such as altered angiogenesis, might participate in tumour neovascularization, while cytokines and membrane proteins which are highly expressed (such as TGF-β2, PD-L1&2) [263] or downregulated (CD32b, Stab-2 and LYVE-1) [264] during CLD may inhibit T-cell antitumoral functions [44] and induce tumour cell proliferation and invasion.