Specifically, polyphenolic compounds such as resveratrol [244,245] or curcumin [208], or the omega-3 fatty acid, docosahexaenoic acid (DHA) [246], have also shown an improvement in different characteristics of CLD, mainly regarding oxidative stress, inflammation and lipid accumulation, accompanied by the amelioration of HSCs, hepatocytes and KC functions [247,248]. The gene discussed is CALCA; the disease is congenital secretory chloride diarrhea 1.