There are a couple of serum biomarkers that are occasionally used in OC diagnostics, serum marker cancer antigen 125 (CA125), human epididymis 4 (HE4) and algorithms based on the above: Risk of Ovarian Cancer Algorithm (ROCA), the Risk of Malignancy Algorithm (ROMA), Risk Malignancy Index (RMI) and Multivariate Index Assay (MIA) [5,6,7,8,9]. The gene discussed is MUC16; the disease is ovarian carcinoma.