In this study, we sought to investigate the cooperation between Ras and BAP1 in ICC pathogenesis by generating autochthonous mice with Cre-mediated conditional activation of mutant Kras and/or deletion of Bap1 alleles within the albumin (Alb) expressing domain, which is comprised of liver progenitor cells, as well as adult hepatocytes and cholangiocytes [40,41]. This evidence concerns the gene BAP1 and intrahepatic cholangiocarcinoma.