Recurrent loss-of-function mutations of the breast cancer type 1 susceptibility protein (BRCA1)-associated protein 1 (BAP1) have also been identified in ICC, along with such mutations in TP53, ARID1A/B, PBRM1, STK11, PTEN, and CKDN2A [28]. This evidence concerns the gene PTEN and intrahepatic cholangiocarcinoma.