BAP1 and intrahepatic cholangiocarcinoma: The fact that ICC development was not observed in BhomoA mice suggests that loss of BAP1 alone does not alter the molecular underpinnings of the cell(s) of origin substantially enough to enable malignant transformation, and we hypothesize that only via the coupling of BAP1 loss with constitutional activation of an oncogene are cells able to undergo malignant transformation.