This was first demonstrated by Salazar et al. [109], who reported that THC induces autophagy in glioma cells via CB1 receptor- and ceramide-dependent phosphorylation of eukaryotic translation initiation factor 2α (eIF2α) and subsequent endoplasmic reticulum stress, induction of the stress-associated transcriptional coactivator p8 and upregulation of tribbles pseudokinase 3 (TRB3). The gene discussed is TRIB3; the disease is central nervous system cancer.