AKT1 and melanoma: In this context, protein kinase B (Akt) inhibition has been repeatedly described as a key event in the growth inhibitory effects of cannabinoids on various types of tumour cells, as shown for instance for CB1 receptor-dependent WIN 55,212-2-induced cell cycle arrest in melanoma cells [106], CB1 receptor dependent HU210- and THC-induced apoptosis of rhabdomyosarcoma cells [97] or CB2 receptor-dependent THC- and JWH-133-induced apoptosis of breast cancer cells [107].