ANGPT2 and central nervous system cancer: Later, the same group found modulation of several hypoxia-related angiogenesis markers by the CB2 receptor agonist JWH-133 in mouse gliomas, including hypoxia-inducible factor-1α, connective tissue growth factor, midkine, Id-3, heme oxygenase-1 and, in addition to Ang-2, its receptor tyrosine kinase, with immunoglobulin-like and EGF-like domains 1 (Tie-1) [150].