Further proteolytic regulations involved in anti-invasive cannabinoid action include downregulation of matrix metalloproteinase (MMP)-2 by THC in glioma cells [140], downregulation of MMP-2 and -9 in hepatocellular carcinoma cells treated with the CB2 receptor agonist CB65 and the CB1 receptor agonist arachidonyl-2′-chloroethylamide (ACEA) [141] and downregulation of plasminogen activator inhibitor-1 (PAI-1) as underlying mechanism of CBD-induced inhibition of lung cancer cell invasion [142]. The gene discussed is SERPINE1; the disease is central nervous system cancer.