The ALDH enzyme family is involved in the detoxification of aldehydes, playing a major role in cell survival, protection and differentiation, [55] and an interesting relationship has been established between ALDH and pesticides toxicity, notably mancozeb or maneb, in the pathophysiology of Parkinson’s and Alzheimer’s diseases [56,57]. The gene discussed is LDHA; the disease is early-onset autosomal dominant Alzheimer disease.