Human anti-FGFR3 mAb, MFGR1877S (Genentech), is a monoclonal antibody against FGFR3 and has been used against multiple myeloma and MFGR1877S and has also shown antitumour activity for overexpressed FGFR3 in preclinical models of bladder cancer [221,229,230,231,232,233]. The gene discussed is FGFR3; the disease is AL amyloidosis.