Using a comprehensive mRNA expression dataset generated by the TCGA Research Network (https://www.cancer.gov/tcga/, accessed on 5 May 2021), we recently demonstrated that high levels of CCNE1 correlated with reduced overall survival of HCC patients (liver hepatocellular carcinoma, LIHC cohort) after diagnosis, while CDK2 expression level had no effect on general patient mortality [10]. This evidence concerns the gene CDK2 and hepatocellular carcinoma.