Concomitantly, the immunoregulatory mediators IL6, IL10 and Cd274, known to be expressed by HCCs, MDSCs, TAMs and myofibroblasts and to promote protumorigenic signalling on cancer (e.g., growth, angiogenesis, metastasis) or microenvironment (e.g., cell migration, immune evasion) [38,39], were attenuated in Ccne1-depleted animals. The gene discussed is CCNE1; the disease is cancer.