When analyzed separately, despite limited patient numbers, each MRD marker detected in trisomy 8 patients associated with a higher CIR (mutation-based MRD p = 0.20; BAALC/ABL1 p = 0.03, MN1/ABL1 p = 0.002, WT1/ABL1 p = 0.004, FISH p = 0.17), resembling the relapse risk observed in AML patients without a trisomy 8 (Supplementary Figure S4). Here, WT1 is linked to acute myeloid leukemia.