Between August 2015 and December 2018, 58 patients with advanced HCC and preserved baseline liver function were treated with anti-PD-1/PD-L1 monoclonal antibodies, given alone or concurrent with either anti-CTLA-4 antibodies and/or targeted agents (including sorafenib, cabozantinib, and an investigational c-Met inhibitor). The gene discussed is CD274; the disease is hepatocellular carcinoma.