This impact of hypoxia is mediated by hypoxia-inducible factors-1α (HIF-1α), which is known to serve as s master regulator of oxygen homeostasis and play key roles in the angiogenesis, tumor invasion, and metastasis of breast cancer cells, as well as the maintenance, survival, and expansion of BCSCs [12,14]. This evidence concerns the gene HIF1A and breast carcinoma.