We have shown that FEZF1 and FEZF1-AS1 mRNA levels correlate strongly in Ewing sarcoma cells and that EWSR1-FLI1 knock-down drastically reduces the levels of FEZF1 and FEZF1-AS1 mRNAs, suggesting a coordinated regulation of both genes, at least in Ewing sarcoma cells. The gene discussed is EWSR1; the disease is Ewing sarcoma.