CD8A and neoplasm: Recently, Klampatsa et al. identified, by flow cytometry analysis on MPM patient samples, a proportion of CD8+ tumor-infiltrated lymphocytes (TIL) and tissue-resident memory (Trm) cells with hypofunction that was related not to the expression of inhibitor molecules but to the higher degree of Tregs in TME and to the expression of the Eomes transcriptional factor, known as regulator of CD8+ cell functions [74].