In addition, MPM tumors harboring LATS1/2 mutation is associated with high PD-L1 expression and rather than NF2-mutant MPM, display enriched Tregs signature and plasma B cell signature [18], suggesting that different tumor-infiltrating immune cell patterns exist between dysregulation of NF2 and Hippo-YAP signaling in MPM. This evidence concerns the gene NF2 and neoplasm.