ANGPT1 and neoplasm: MTAs like the taxanes downregulate the expression of Angiopoietin-1 (Ang-1), a protein required for vascular development and angiogenesis [200], and upregulate the expression and increased secretion of Thrombospondin 1 in the tumor microenvironment, a protein that is able to inhibit the formation of new blood vessels [201,202].