Characteristic alterations, such as DNMT3, NPM1, IDH1/2, RUNX1, and TP53 mutations prevalent in adult de-novo AML, occur with much lower prevalence in children, while the NRAS, KIT, KRAS, WT1, CBL, GATA2, ASXL2, SETD2, and some additional genes more commonly affect children [15]. The gene discussed is RUNX1; the disease is acute myeloid leukemia.