RUNX1 and acute lymphoblastic leukemia: In pediatric ALL, favorable prognostic genetic events include ETV6-RUNX1 fusion, ETV6-RUNX1-like expression pattern, DUX4 rearrangement, and high hyperdiploid karyotype, while BCR-ABL1 fusion, intrachromosomal amplification of chromosome 21 (iAMP21), IKZF1plus copy number profile, and TCF3-HLF fusion are associated with inferior outcomes [131,132].