Cases with distinctive and confirmed BCP-ALL subtypes again clustered together, while for a subset of cases without known genomic alterations, we observed their co-clustering with these confirmed BCP-ALL subtypes, namely BCR-ABL1 (n = 59), ETV6-RUNX1 (n = 13) and ZNF384-rearranged (n = 1), representing a previously reported subgroup of cases with expression profiles similar to the mentioned subtypes. The gene discussed is ZNF384; the disease is acute lymphoblastic leukemia.