In the subsequent studies, the heterogeneous B-other subgroup was further dissected, resulting in the discovery of new leukemia driving alterations, e.g., MEF2D, ZNF384 and NUTM1 rearranged [19,20,21,22,23], as well as heterogeneous subgroups with expression profiles similar to classic BCP-ALL subtypes, e.g., ETV6-RUNX1-like [24]. The gene discussed is RUNX1; the disease is acute lymphoblastic leukemia.