CD4 and neoplasm: On the other hand, multiple studies reported that the levels of CD8 T cell-expressed miR-155 associate with optimal T cell receptor (TCR)-induced activity of tumor-infiltrating CD8 T cells (TILs), increased IFN-γ responses in both CD4 and CD8 T cells through a mechanism involving Ship1 repression, and to a better control of tumor growth [72,73,74,75].