ABCA3 and ovarian cancer: Both ABCA3 and ABCC3 have well-established roles in the efflux of anthracycline and methotrexate/epipodophyllotoxin chemotherapy substrates, respectively [38], with several studies reporting ABCA3 (known for its role in the production of pulmonary surfactant) to be upregulated in cisplatin-resistant ovarian cancer cells [15].