Although most naïve mtEGFR-expressing NSCLC cells are initially sensitive to EGFR TKI treatment [15,17,187,188], acquired resistance eventually happens [189,190,191,192,193,194,195] and AXL and/or GAS6 are frequently upregulated [53,58,196,197]. This evidence concerns the gene EGFR and non-small cell lung carcinoma.